Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study.

ABSTRACT:

Introduction

Vitamin D deficiency is associated with adverse pregnancy events. However, its role in the etiology of congenital anomalies remains unclear. We examined the association between vitamin D status, measured through prepregnancy diet, UV exposure, season of conception, and congenital anomalies.

Methods

We used data from the National Birth Defects Prevention Study, a U.S. population-based case-control study (1997-2011). Prepregnancy dietary vitamin D was calculated from food frequency questionnaires and evaluated using tertiles, based on the distribution in controls. We used the National Oceanic and Atmospheric Administration Weather Service to assign UV indices based on location and estimated date of conception, then dichotomized UV exposure (low vs. high). Seasons

SUBMITTER: Adrien N 

PROVIDER: S-EPMC11841983 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature