Impact of liver-specific survival motor neuron (SMN) depletion on central nervous system and peripheral tissue pathology.

ABSTRACT: Spinal muscular atrophy (SMA) is caused by mutations in the Survival Motor Neuron 1 (SMN1) gene. While traditionally viewed as a motor neuron disorder, there is involvement of various peripheral organs in SMA. Notably, fatty liver has been observed in SMA mouse models and SMA patients. Nevertheless, it remains unclear whether intrinsic depletion of SMN protein in the liver contributes to pathology in the peripheral or central nervous systems. To address this, we developed a mouse model with a liver-specific depletion of SMN by utilizing an Alb-Cre transgene together with one Smn^2B allele and one Smn1 exon 7 allele flanked by loxP sites. Initially, we evaluated phenotypic changes in these mice at postnatal day 19 (P19), when the severe model of SMA, th

SUBMITTER: de Almeida MMA 

PROVIDER: S-EPMC11841985 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature