Diminished Mycobacterium tuberculosis-specific T-cell Responses During Pregnancy in Women With HIV and Receiving Isoniazid Preventive Therapy.

ABSTRACT:

Background

Pregnancy increases Mycobacterium tuberculosis (Mtb) reactivation risk and alters immune responses. We assessed Mtb-specific CD4+ T-cell responses in pregnant women with HIV (WLHIV) and without, including those receiving isoniazid preventive therapy (IPT).

Methods

We measured adaptive immune responses from 33 participants (HIV+ 21, HIV- 12) with positive interferon-gamma release assay during pregnancy (20-34 weeks' gestation), 6 weeks, and 12 months postpartum by intracellular cytokine staining. We measured overall responses using COMPASS and made comparisons by nonparametric analysis of variance.

Result

We observed diminished Mtb-specific CD4+ T-cell responses in WLHIV during pregnancy versus 12 months postpartum (COMPASS median functional score [FS

SUBMITTER: Saha A 

PROVIDER: S-EPMC11842132 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature