Associations of depression and perceived physical fatigability with white matter integrity in older adults.

ABSTRACT:

Backgrounds

Fatigability is prevalent in older adults. However, it is often associated with depressed mood. We aim to investigate these two psychobehavioral constructs by examining their underpinning of white matter structures in the brain and their associations with different medical conditions.

Methods

Twenty-seven older adults with late-life depression (LLD) and 34 cognitively normal controls (CN) underwent multi-shell diffusion MRI. Fatigability was measured with the Pittsburgh Fatigability Scale. We examined white matter integrity by measuring the quantitative anisotropy (QA), a fiber tracking parameter with better accuracy than the traditional imaging technique.

Results

We found those with LLD had lower QA in the 2nd branch of the left superior longitudinal fasc

SUBMITTER: Lin C 

PROVIDER: S-EPMC11842153 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature