High-Sensitivity Troponin T, NT-proBNP, and Cognitive Outcomes in SPRINT.

ABSTRACT:

Background

Hs-cTnT (cardiac troponin T measured with a highly sensitive assay) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) may identify adults with hypertension who derive greater cognitive benefits from lower systolic blood pressure targets.

Methods

In the SPRINT (Systolic Blood Pressure Intervention Trial) MIND study, participants were categorized as having both hs-cTnT and NT-proBNP in the lower 2 tertiles (n=4226), one in the highest tertile (n=2379), and both in the highest tertile (n=1506). We assessed the effect of intensive versus standard treatment on the composite of mild cognitive impairment (MCI) or probable dementia (PD) across biomarker categories.

Results

Over a median follow-up of 5.1 years, 830 of 8111 participants (10.2%) developed MCI

SUBMITTER: Haney D 

PROVIDER: S-EPMC11842154 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature