Specialized pro-resolving mediator Maresin 1 attenuates pain in a mouse model of osteoarthritis.

ABSTRACT:

Objective

We test whether the specialized pro-resolving molecule Maresin 1 (MaR1) attenuates nociceptive behaviors in mice with osteoarthritis-like pain.

Design

Osteoarthritis (OA)-like pain behavior was induced by intra-articular injection of monosodium iodoacetate (MIA) and treated with MaR1 (N=6) or vehicle (N=5) by intraperitoneal injection 8 weeks after injury. Mice without MIA injection were used as control (N=6). Nociceptive behaviors were examined by von Frey and dynamic weight bearing measurements. Calcitonin gene-related peptide (CGRP) expression and activated macrophages in the dorsal root ganglion (DRG) were examined by immunofluorescence staining. The inflammatory profile in circulation was assessed by cytokine array. Calcium imaging was performed to assess the

SUBMITTER: Shih YV 

PROVIDER: S-EPMC11842212 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature