Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice.

ABSTRACT:

Background

Liver diseases pose significant health challenges, underscoring the importance of understanding liver regeneration mechanisms. Systemic adipose tissue is thought to be a primary source of lipids and energy during this process; however, empirical data on the effects of adipose tissue deficiency are limited. This study investigates the role of adipose tissue in liver regeneration, focusing on transient regeneration-associated steatosis (TRAS) and hepatocyte proliferation using a Seipin knockout mouse model that mimics severe human lipodystrophy. Additionally, the study explores therapeutic strategies through adipose tissue transplantation.

Methods

Male Seipin knockout (Seipin^-/-) and wild-type (WT) mice underwent 2/3 partial hepatectomy (PHx). Liver and p

SUBMITTER: Dong Q 

PROVIDER: S-EPMC11842221 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature