A Population-Based Correlation Analysis Between Hemoglobin A1c and Hemoglobin Levels.

ABSTRACT:

Background

Glycated hemoglobin (HbA1c) is widely used to assess long-term glycemic control in individuals with diabetes. However, various conditions that affect hemoglobin levels or the lifespan of red blood cells can compromise the accuracy of HbA1c measurements. Despite extensive research, the relationship between HbA1c and hemoglobin remains unclear. This study aims to clarify this relationship by examining its correlation across diverse age and gender cohorts.

Methods

Data from 217,991 participants aged 20 to 69 years were collected from health examination centers in Southwest China. Standardized methodologies were used to measure HbA1c and hemoglobin levels. Generalized additive models (GAM) were utilized to analyze non-linear relationships and adjust for potential conf

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11842278 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature