An untargeted metabolome-wide association study of maternal perinatal tobacco smoking in newborn blood spots.

ABSTRACT:

Introduction

Maternal tobacco smoking in the perinatal period increases the risk for adverse outcomes in offspring.

Objective

To better understand the biological pathways through which maternal tobacco use may have long-term impacts on child metabolism, we performed a high-resolution metabolomics (HRM) analysis in newborns, following an untargeted metabolome-wide association study workflow.

Methods

The study population included 899 children without cancer diagnosis before age 6 and born between 1983 and 2011 in California. Newborn dried blood spots were collected by the California Genetic Disease Screening Program between 12 and 48 h after birth and stored for later research use. Based on HRM, we considered mothers to be active smokers if they were self- or provider-r

SUBMITTER: He D 

PROVIDER: S-EPMC11842421 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature