Clinical utility of tumor-infiltrating lymphocyte evaluation by two different methods in breast cancer patients treated with neoadjuvant chemotherapy.

ABSTRACT:

Purpose

The aim of this study was to examine the clinical utility of tumor-infiltrating lymphocytes (TILs) evaluated by "average" and "hot-spot" methods in breast cancer patients.

Methods

We examined 367 breast cancer patients without neoadjuvant chemotherapy (NAC) by average and hot-spot methods to determine the consistency of TIL scores between biopsy and surgical specimens. TIL scores before NAC were also compared with the pathological complete response (pCR) rate and clinical outcomes in 144 breast cancer patients that received NAC. TIL scores evaluated by the two methods were predicted from clinicopathological data using random forest regression.

Results

Surgical specimens showed higher TIL scores than biopsy specimens using the hot-spot method (p < 0.001), while

SUBMITTER: Nagahashi M 

PROVIDER: S-EPMC11842476 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature