Tumor infiltration of inactive CD8 + T cells was associated with poor prognosis in Gastric Cancer.

ABSTRACT:

Background

Gastric cancer (GC) shows limited response to immune checkpoint inhibitors due to its complex tumor immune microenvironment (TIME). This study explores the functions of various immune cells in the complex TIME in GC.

Methods

We assessed CD8 + T-cell infiltration of GC tissues by immunohistochemistry, and performed single-cell RNA sequencing (scRNA-seq) of tumor and normal tissues from 34 patients with GC.

Results

We categorized 157 GC patients into LOW, MID, and HIGH groups based on their CD8 + T-cell infiltration. Overall survival was notably lower for the HIGH and LOW groups compared with the MID group. Our scRNA-seq data analysis showed that CD8 + T-cell activity markers in the HIGH group were expressed at lower levels than in normal tissue, but the T-ce

SUBMITTER: Katayama N 

PROVIDER: S-EPMC11842491 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature