Nationwide survey on HER2 and PD-L1 testing practices in gastric cancer across Japan.

ABSTRACT:

Background

Since HER2 and PD-L1 testing are key to selecting drugs for first-line treatments in advanced gastric cancer, evaluating differences in these tests among institutions is necessary to standardize treatment.

Methods

A questionnaire survey was conducted targeting institutions certified by the Japanese Gastric Cancer Association.

Results

Responses were obtained from 155 institutions. Most institutions performed HER2 testing in-house, while PD-L1 tests were largely outsourced. HER2 scores and PD-L1 CPS rates showed greater variability across institutions than anticipated. In the pre-analytic phase, 10% neutral buffered formalin was commonly used, with fixation practices generally following guidelines. Overall, the impact of fixation-related factors was limited,

SUBMITTER: Abe H 

PROVIDER: S-EPMC11842516 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature