Development and validation of a new equation to estimate glomerular filtration rate in Argentinian adults.

ABSTRACT: Latin Americans are underrepresented in the current equations used to estimate glomerular filtration rate (GFR), and the applicability of their predictions to this population may therefore be questionable. The objective of this study was to develop a new equation to estimate GFR based on data from Argentina. A cross-sectional study was conducted. We included 583 Argentinian adults in development sample (DS) and 78 in temporary validation sample (TVS). Urinary iothalamate clearance (reference method), and different predictive variables were used to develop candidate equations to estimate GFR. The performance was assessed through 10-fold cross-validation in DS, and by direct validation in TVS, using root mean squared error (RMSE), correlation (r), bias, P15, P30 and correct classification pe

SUBMITTER: Fernandez P 

PROVIDER: S-EPMC11842545 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature