Ketogenic diet suppresses colorectal cancer through the gut microbiome long chain fatty acid stearate.

ABSTRACT: Colorectal cancer (CRC) patients have been shown to possess an altered gut microbiome. Diet is a well-established modulator of the microbiome, and thus, dietary interventions might have a beneficial effect on CRC. An attenuating effect of the ketogenic diet (KD) on CRC cell growth has been previously observed, however the role of the gut microbiome in driving this effect remains unknown. Here, we describe a reduced colonic tumor burden upon KD consumption in a CRC mouse model with a humanized microbiome. Importantly, we demonstrate a causal relationship through microbiome transplantation into germ-free mice, whereby alterations in the gut microbiota were maintained in the absence of continued selective pressure from the KD. Specifically, we identify a shift toward bacterial species that pr

SUBMITTER: Tsenkova M 

PROVIDER: S-EPMC11842570 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature