The Modulation by the Locus Coeruleus of Recent and Remote Memory Retrieval is Activity-Dependent.

ABSTRACT: The hippocampus plays a crucial role in acquiring, storing, and retrieving associative experience. Whereas neuromodulatory control of the hippocampus by the locus coeruleus (LC) enhances memory acquisition and consolidation, less is known about its influence on memory retrieval. The LC fires at tonic (0.5-8 Hz) and phasic frequencies (10-25 Hz), relative to arousal and affective states. Here, we explored to what extent LC stimulation at different frequencies (2-100 Hz) and respective stimulation patterns, before retrieval of recently acquired or remote spatial memory, alter working memory (WM) or reference memory (RM) in male rats. Here, animals learned a spatial memory task in an eight-arm radial maze over a period of 15 days. LC stimulation before recent memory testing did not affect WM.

SUBMITTER: Babushkina N 

PROVIDER: S-EPMC11842585 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature