Myelodysplastic syndromes with del(20q) transformed into B-lineage acute lymphoblastic leukemia remaining with del(20q): a case report with literature review.

ABSTRACT:

Background

The transformation of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML) is common, while it is extremely rarely for acute lymphoblastic leukemia (ALL) transformation. Herein, we described the clinical and cytogenetic features of a case of MDS with del(20q) transformed into B-lineage ALL (B-ALL) remaining with del(20q).

Case presentation

A 66-year-old Chinese man who presented with pancytopenia, bone marrow hypercellularity and obvious megakaryocytes dysplasia were admitted for treatment. Karyotype analysis of leukemic cells revealed the clonal abnormality of del(20q) and he was diagnosed with MDS carrying del(20q). He was administrated with Danazol, cyclosporin A, and lenalidomide for 3 months, and then discontinued due to poor efficacy, severe swe

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11842640 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature