Genetically predicted inflammatory proteins mediate the association between gut microbiota and renal cell carcinoma.

ABSTRACT:

Background

Studies have indicated a potential relationship between gut microbiota and renal cell carcinoma. However, the causal relationship between various types of gut microbiota and renal cell carcinoma, as well as the role of inflammatory protein as mediators, remains unclear.

Methods

This study aimed to identify the relationship between gut microbiota, inflammatory protein, and renal cell cancer through a large-scale genome-wide association study (GWAS) utilizing pooled data. We employed Mendelian randomization (MR) to investigate the causal relationship among these variables. Inverse variance weighting (IVW) was utilized as the primary statistical method. Furthermore, we examined the mediating role of inflammatory protein in the pathway through which gut microbiota inf

SUBMITTER: Zou X 

PROVIDER: S-EPMC11842667 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature