Identifying Specificity Protein 2 as a key marker for diabetic encephalopathy in the context of predictive, preventive, and personalized medicine.

ABSTRACT:

Background

Transcription factor specificity protein (SP2) regulates various cellular functions, including cell division, proliferation, invasion, metastasis, differentiation, and death; however, its role has not been studied in prominent medical conditions including diabetic encephalopathy (DE). Therefore, this study addressed its physiological function in the context of DE to also better characterize its possible use in the context of predictive, preventive, and personalized medicine (PPPM).

Methods

The anti-inflammatory and anti-DE actions of SP2 were investigated using three animal models (SP2^-/- mice, streptozocin-treated mice, and db/db mice) and two cell lines (primary cultured hippocampal neurons and N2A cells). The db/db mice were a leptin deficiency model

SUBMITTER: Tao G 

PROVIDER: S-EPMC11842694 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature