Group B Streptococcus growth in human urine is associated with asymptomatic bacteriuria rather than urinary tract infection and is unaffected by iron sequestration.

ABSTRACT: Group B Streptococcus (GBS) causes various infections in adults, including urinary tract infection (UTI) and asymptomatic bacteriuria (ABU). Some bacteria that cause ABU can utilize urine as a substrate for growth, which can promote asymptomatic colonization in the host. An analysis of diverse GBS isolates associated with ABU and UTI for growth in human urine has not been undertaken. Here, we examined a large collection of clinical urinary GBS isolates from individuals with acute UTI (n=62), and ABU with bacteriuria ≥10⁴ c.f.u. ml^-1 (n=206) or <10⁴ c.f.u. ml^-1 (n=90) for their ability to grow in human urine. Among all 358 GBS isolates analysed, 40 exhibited robust growth in urine in contrast to 25 that were unable to g

SUBMITTER: Ipe DS 

PROVIDER: S-EPMC11842879 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature