Adverse pregnancy outcomes, familial predisposition, and cardiovascular risk: a Swedish nationwide study.

ABSTRACT:

Background and aims

Adverse pregnancy outcomes (APOs) are recognized as significant female-specific risk factors for cardiovascular disease (CVD). A potential shared familial susceptibility between APOs and CVD has been proposed, but not thoroughly explored. This study employs a quasi-experimental family comparison design to investigate shared familial predisposition between APOs and CVD, by assessing risk of CVD in APO-exposed women and their APO-free sisters.

Methods

Nationwide population-based cohort study encompassing primiparous women, without prior CVD, with registered singleton births in the Swedish Medical Birth Register between 1992 and 2019, grouped into: women with ≥1 APO (165 628), APO-free sisters (60 769), and unrelated APO-free comparator women (992 108). All

SUBMITTER: Mantel A 

PROVIDER: S-EPMC11842972 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature