Mimicry-based strategy between human and commensal antigens for the development of a new family of immune therapies for cancer.

ABSTRACT:

Background

Molecular mimicry between commensal bacterial antigens and tumor-associated antigens (TAAs) has shown potential in enhancing antitumor immune responses. This study leveraged this concept using commensal bacterial antigens, termed OncoMimics, to induce TAA-derived peptide (TAAp)-specific cross-reactive cytotoxic T cells and improve the efficacy of peptide-based immunotherapies.

Methods

The discovery of OncoMimics primarily relied on a bioinformatics approach to identify commensal bacteria-derived peptide sequences mimicking TAAps. Several OncoMimics peptide (OMP) candidates were selected in silico based on multiple key parameters to assess their potential to elicit and ameliorate immune responses against TAAs. Selected OMPs were synthesized and tested for their aff

SUBMITTER: Talpin A 

PROVIDER: S-EPMC11842988 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature