Changes in faecal haemoglobin values over sequential rounds of faecal immunochemical tests (FIT) in a surveillance population.

ABSTRACT:

Objective

Colorectal cancer (CRC) screening enables resection of polyp precursor lesions, preventing cancer or detecting it earlier. Post-polypectomy, people can remain at increased CRC risk, prompting surveillance colonoscopy. Less invasive faecal immunochemical tests (FIT) could reduce the burden of surveillance colonoscopy. We investigated whether changes in FIT values over multiple rounds were associated with advanced colorectal neoplasia (ACN) detection.

Methods

A cohort of men and women aged 60-72 years deemed intermediate risk by the 2002 UK adenoma surveillance guidelines and scheduled for three yearly colonoscopies were recruited (January 2012-December 2013) within the English Bowel Cancer Screening Programme and offered a quantitative FIT at 1, 2 and 3 years post-b

SUBMITTER: Mortell G 

PROVIDER: S-EPMC11843008 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature