Comparison of Efficacies of a Blonanserin Transdermal Patch and Blonanserin Oral Formulation for Psychiatric Symptoms in Patients With Schizophrenia Treated With Laxatives Using a Japanese Claims Database.

ABSTRACT:

Background

Laxative use has recently been indicated as a risk factor for hospitalization in patients with schizophrenia. Oral antipsychotic therapy for patients with schizophrenia treated with laxatives may be problematic due to gastrointestinal dysfunction, which affects absorption. Therefore, transdermal patches of antipsychotics may be a suitable alternative. We herein compared the efficacies of a blonanserin (BNS) patch and BNS oral formulation in patients with schizophrenia treated with laxatives.

Methods

A retrospective cohort study was performed using a claims database in Japan provided by DeSC Healthcare Inc. Subjects were BNS patch- or BNS oral formulation-prescribed patients with schizophrenia. The primary outcome was hospitalization to psychiatric wards. The hazar

SUBMITTER: Inada K 

PROVIDER: S-EPMC11843157 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature