Changes of Peripheral T Cells in Systemic Lupus Erythematosus Patients.

ABSTRACT:

Background

Efficient indicators for evaluating the imbalance of lymphocyte function were crucial to clinical therapy in systemic lupus erythematosus (SLE) patients. This study aimed to find biomarkers to assess lymphocyte-mediated immune response in SLE patients.

Methods

A total of 81 SLE patients (non-active: n = 35, active: n = 46) and 70 healthy donors were recruited in the study. Peripheral blood was obtained, and flow cytometry was used to detect circulating lymphocytes.

Results

Data showed that the counts of CD3⁺T, CD4⁺T, CD8⁺ T, and NK cells were decreased in active SLE patients compared with non-active SLE patients and healthy donors. The counts of peripheral T cells were increased in responders but decreased in non-responders

SUBMITTER: Lao J 

PROVIDER: S-EPMC11843224 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature