Performance of 8 Smoking Metrics for Modeling Survival in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Importance

Cigarette smoking is a strong risk factor for mortality in patients diagnosed with head and neck squamous cell carcinoma (HNSCC). However, little evidence supports which smoking metric best models the association between smoking and survival in HNSCC.

Objective

To determine which smoking metric best models a linear association between smoking exposure and overall survival (OS) in patients with HNSCC.

Design, setting, and participants

A retrospective multicenter cohort study of 6 clinical epidemiological studies was performed. Five were part of the Human Papillomavirus, Oral and Oropharyngeal Cancer Genomic Research (VOYAGER) consortium. Participants included patients 18 years and older with pathologically confirmed HNSCC. Data were collected from January 20

SUBMITTER: Lam ACL 

PROVIDER: S-EPMC11843462 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature