Likelihood of sampling prostate cancer at systematic biopsy as a function of gland volume and number of cores.

ABSTRACT:

Background

Pre-biopsy multiparametric magnetic resonance imaging (mpMRI) of the prostate is used to conduct targeted prostate biopsy (TB), guided by ultrasound and registered (fused) to the MRI. Systematic biopsy (SB) continues to be used together with TB or in mpMRI-negative patients. There is insufficient evidence on how to use SB to inform clinical decision-making in the mpMRI era. The purpose of this study was to estimate the effect of prostate volume and number of SB cores on sampling clinically significant prostate cancer (csPCa) using a simulation method based on clinical data.

Methods

SBs were simulated using data from 42 patients enrolled in a transrectal ultrasound robot-assisted biopsy trial. Linear mixed models were used to examine the relationship between the nu

SUBMITTER: Rezaee ME 

PROVIDER: S-EPMC11843544 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature