Targeting LncRNA-Vof16: A Novel Therapeutic Strategy for Neuropathic Pain Relief.

ABSTRACT:

Aims

Neuropathic pain (NP) is a debilitating condition characterized by chronic pain resulting from nerve damage or lesion. Despite the ongoing efforts of clinically defining NP, its distinctive mechanisms that lead to various NP phenotypes remain unresolved.

Methods

Using a spared nerve injury (SNI) model, we investigated the mechanisms underlying the development of NP caused by injury in the peripheral nerves. With CRISPR-Cas9-mediated knockout and virus-mediated overexpression strategies, we investigated the role of LncRNA Vof16 (abbreviated as Vof16) during SNI-induced NP.

Results

Our results revealed that SNI led to the downregulation of Vof16 expression in spinal dorsal horn (SDH) of lumbar enlargement. This was evidently confirmed when we disrupted the expressi

SUBMITTER: He X 

PROVIDER: S-EPMC11843576 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature