Innovative MXene/SilMA-Based Conductive Bioink for Three Dimensional Bioprinting of Neural Stem Cell Spheroids in Neural Tissue Engineering.

ABSTRACT: Conductive bioinks, integrated with 3D bioprinting and electrical stimulation, are essential for advancing neural tissue engineering. This study developed a SilMA/Pectin/MXene-soybean phospholipids (SP) bioink, where SilMA (silk fibroin modified with glycidyl methacrylate) provides a structural base, pectin enhances printability and shear-thinning properties, and MXene-SP improves conductivity through superior dispersibility. Increasing pectin and MXene-SP concentrations reduced the hydrogel's Young's modulus, promoting neural stem cell (NSC) differentiation into neurons. Electrochemical analyses revealed that higher MXene-SP levels decreased impedance and increased redox current, while conductivity measurements showed improved performance compared to unmodified MXene. NSCs encapsulated in

SUBMITTER: Yeh YC 

PROVIDER: S-EPMC11843594 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature