Use of tranexamic acid in hepatectomy under controlled low central venous pressure: a randomized controlled study.

ABSTRACT:

Objective

The objective of this study was to investigate the efficacy and safety of tranexamic acid (TXA) in hepatectomy when administered as per the standardized protocol of controlled low central venous pressure (CLCVP).

Methods

This study was a randomized, double-blind, controlled study. Patients who fulfilled the inclusion criteria were randomly assigned to the TXA group (group T) or the placebo group (group N). The central venous pressure (CVP) was maintained at below 5 cmH2O before complete dissection of the liver parenchyma. Patients in group T received an intravenous infusion of 10 mg/kg of TXA 30 min before surgery, and it was continuously pumped intravenously at a rate of 1 mg/(kg.h) until the end of surgery. Patients in group N were infused with 1 mL/kg of normal

SUBMITTER: Luo JY 

PROVIDER: S-EPMC11843753 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature