Multifaceted environmental factors linked to metabolic dysfunction-associated fatty liver disease: an environment-wide association study.

ABSTRACT:

Background

Environmental factors, or exposome, are non-negligible contributors to the occurrence and progression of metabolic dysfunction-associated fatty liver disease (MAFLD). Therefore, this environment-wide association study (EWAS) aimed to investigate the associations between multifarious environmental factors and MAFLD among the general adult population in the United States.

Methods

Eligible participants were obtained from the National Health and Nutrition Examination Survey 2005-2020 cycles. Survey-weighted multivariate logistic regression models were constructed to identify and tentatively validate MAFLD-associated environmental factors. The least absolute shrinkage and selection operator (LASSO) regression was conducted to identify tentatively validated environmenta

SUBMITTER: Dong R 

PROVIDER: S-EPMC11843789 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature