Association Between Vitamin D Receptor BsmI Polymorphism and Low Bone Mineral Density in Postmenopausal Women in the MENA Region.

ABSTRACT:

Background/objectives

Low bone mineral density increases the risk of bone fractures, and this condition is especially common in postmenopausal women. Genetic factors significantly influence bone mineral density. This meta-analysis examined the relationship between vitamin D receptor (VDR) gene polymorphisms (BsmI, ApaI, and TaqI) and bone mineral density in postmenopausal women in the Middle East and North Africa (MENA) region.

Methods

The PubMed, Embase, Scopus, and Web of Science databases were searched from inception to March 2024 for case-control studies on VDR BsmI, ApaI, and TaqI polymorphisms and their relationship with low bone density. Associations with low bone mineral density were tested with respect to different genetic models (dominant, recessive, allelic) using

SUBMITTER: Al-Barazenji T 

PROVIDER: S-EPMC11843856 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature