A Scoping Review on Cognition in Myelodysplastic Syndromes: Advances and Challenges.

ABSTRACT:

Background/objectives

Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis and a risk of progression to acute myeloid leukemia (AML). Cognitive impairments, including deficits in memory, attention, and executive function, are frequently reported in MDS patients. These impairments are linked to systemic inflammation, neurotoxic treatment effects, and the psychological burden of chronic disease. This review synthesizes existing evidence on cognitive dysfunction in MDS, highlighting knowledge gaps and opportunities for future research.

Methods

A scoping review was conducted following PRISMA-ScR guidelines. MEDLINE and Scopus databases were searched for studies examining cognition in MDS patients, using terms like "myelody

SUBMITTER: Tsiakiri A 

PROVIDER: S-EPMC11843857 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature