A novel recombinant PHB production platform in filamentous cyanobacteria avoiding nitrogen starvation while preserving cell viability.

ABSTRACT: During the past decades, the importance of developing sustainable, carbon dioxide (CO₂)-neutral and biodegradable alternatives to conventional plastic has become evident in the context of global pollution issues. Therefore, heterotrophic bacteria such as Cupriavidus sp. have been intensively explored for the synthesis of the biodegradable polymer polyhydroxybutyrate (PHB). PHB is also naturally produced by a variety of phototrophic cyanobacteria, which only need sunlight and CO_2, thereby allowing a CO₂ negative, eco-friendly synthesis of this polymer. However, a major drawback of the use of cyanobacteria is the need of a two-stage production process, since relevant amount of PHB synthesis only occurs after transferring the cultures to conditions of nitrogen

SUBMITTER: Fink P 

PROVIDER: S-EPMC11844001 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature