Omics data integration analysis identified new biological insights into chronic antibody-mediated rejection (CAMR).

ABSTRACT:

Background

In the last two decades, many studies based on omics technologies have contributed to defining the clinical, immunological, and histological fingerprints of chronic antibody-mediated rejection (CAMR), the leading cause of long-term kidney allograft failure. However, the full biological machinery underlying CAMR has only been partially defined, likely due to the fact thatsingle-omics technologies capture only specific aspects of the biological system and fail to provide a comprehensive understanding of this clinical complication.

Methods

This study integrated mass spectrometry-based proteomic profiling of serum samples from 19 patients with clinical and histological evidence of CAMR and 26 kidney transplant recipients with normal graft function and histology (CTR)

SUBMITTER: Bruschi M 

PROVIDER: S-EPMC11844005 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature