Mechanistic insights into the role of EGLN3 in pulmonary vascular remodeling and endothelial dysfunction.

ABSTRACT: Endothelial dysfunction is a pivotal initiating factor in vascular remodeling in pulmonary hypertension. EGLN3, a hypoxia response factor, plays a significant role in cell proliferation and angiogenesis, which are closely related to the pathophysiological conditions of pulmonary hypertension. This study investigates the potential involvement of EGLN3 in the injury response of pulmonary vascular endothelial cells and its contribution to the development of pulmonary arterial hypertension. Research has demonstrated that in patients with pulmonary arterial hypertension and various animal models of the condition, EGLN3 expression is upregulated in the remodeled pulmonary artery endothelium. Notably, the endothelial cell-specific knockout of EGLN3 can decelerate the progression of pulmonary arte

SUBMITTER: Deng X 

PROVIDER: S-EPMC11844033 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature