The phenogenomic landscapes of pleural mesothelioma tumor microenvironment predict clinical outcomes.

ABSTRACT:

Background

Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy with limited therapeutic options. To improve patients management and treatment, more precise stratification strategies are needed. This study aimed to characterize the phenogenomic landscapes of MPM and to understand their influence on patients clinical outcomes.

Methods

We conducted a phenogenomic analysis on 22 MPM patients using two high throughput approaches: imaging mass cytometry (IMC) with whole exome sequencing (WES). Resulting profiles were addressed for their clinical relevance to predict patients prognosis.

Results

IMC revealed a highly heterogeneous tumor microenvironment (TME) with distinct tumor cell subpopulations. Notably, we identified a novel sarcomatoid-like cellular

SUBMITTER: Torricelli F 

PROVIDER: S-EPMC11844119 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature