Bio-3D printing of scaffold-free ADSC-derived cartilage constructs comparable to natural cartilage in vitro.

ABSTRACT:

Background

In end-stage osteoarthritis (OA), osteochondral defects reach the subchondral bone and cartilage tissue of sufficient thickness is required to compensate for the defects. Adipose-derived mesenchymal stem/stromal cells (ADSCs), which are abundant in the body, have the potential to differentiate into cartilage and may be a useful cell source for cartilage regeneration. If it is possible to fabricate ADSC-derived cartilage constructs that can cover the damaged area, this could lead to the development of a new regenerative therapy for OA that could replace the currently available treatments. We therefore sought to produce cartilage constructs with suitable thickness and biological properties, similar to native cartilage, using the bio-three-dimensional (3D) printer. We also

SUBMITTER: Nonaka T 

PROVIDER: S-EPMC11844123 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature