The potential application of isoxanthohumol in inhibiting Clostridium perfringens infection by targeting the type IV pili.

ABSTRACT:

Background

Clostridium perfringens (C. perfringens) is an important zoonotic pathogen. The diseases such as necrotic enteritis (NE), enterotoxemia, gas gangrene and food poisoning caused by its infection seriously threaten the lives of both humans and animals. However, under the severe situation of antibiotic resistance, the development of new antibacterial strategies or drugs deserves great attention.

Results

In this study, we selected the virulence factor Type IV pili (TFP) of C. perfringens as the target for drug screening. The gliding motility, biofilm formation, cell adhesion and antibacterial activity of the natural compound isoxanthohumol (IXN) against C. perfringens were determined. Transmission electron microscopy (TEM), TFP gene transcription analysis and Western b

SUBMITTER: Song Z 

PROVIDER: S-EPMC11844124 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature