Matrix metalloproteinases and their tissue inhibitors as upcoming biomarker signatures of connective tissue diseases-related interstitial lung disease: towards an earlier and accurate diagnosis.

ABSTRACT:

Background

Lack of understanding of interstitial lung disease (ILD) associated with systemic sclerosis (SSc) and rheumatoid arthritis (RA) hinders the early and accurate identification of these devastating diseases. Current clinical tools limitations highlight the need to complement them with accessible and non-invasive methods. Accordingly, we focused on identifying useful matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) as new biomarkers with clinical value in the diagnosis and prognosis of RA-ILD⁺ and SSc-ILD⁺.

Methods

Peripheral blood was collected from patients with RA-ILD⁺ (n = 49) and SSc-ILD⁺ (n = 38); as well as with RA-ILD^- (n = 25), SSc-ILD^- (n = 20) and idiopathic pulmonary fibr

SUBMITTER: Pulito-Cueto V 

PROVIDER: S-EPMC11844142 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature