Intra and inter-organ communication through extracellular vesicles in obesity: functional role of obesesomes and steatosomes.

ABSTRACT:

Background

Extracellular vesicles (EVs) represent a sophisticated mechanism of intercellular communication that is implicated in health and disease. Specifically, the role of EVs in metabolic regulation and their implications in metabolic pathologies, such as obesity and its comorbidities, remain unclear.

Methods

Extracellular vesicles (EVs) were isolated through serial ultracentrifugation from murine adipocytes treated with palmitate or oleic acid, whole visceral and subcutaneous adipose tissue (obesesomes) of bariatric surgery obese donors, and human hepatocytes under steatosis (steatosomes) for functional in vitro experiments. Functional effects on inflammation and glucose and lipid metabolism of target cells (human and murine macrophages and hepatocytes) were assessed us

SUBMITTER: Lago-Baameiro N 

PROVIDER: S-EPMC11844161 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature