SEC61G Facilitates Brain Metastases via Antagonizing PGAM1 Ubiquitination and Immune Microenvironment Remodeling in Non-Small Cell Lung Cancer.

ABSTRACT: Background: Brain metastases are a leading cause of mortality in non-small cell lung cancer (NSCLC), yet their molecular mechanisms remain unclear. SEC61G, a subunit of the SEC61 translocon, has been implicated in tumor progression but its role in brain metastases is unknown. This study explores how SEC61G contributes to brain metastases by driving metabolic reprogramming and immune microenvironment remodeling. Methods: Brain-metastatic NSCLC cell lines were established through in vivo selection in a mouse model. SEC61G expression was analyzed via transcriptomics, immunohistochemistry, multiplex immunofluorescence, and patient datasets. Functional assays were used to assess SEC61G's role in glycolysis, TLS formation, and immune interactions, with a focus on the SEC61G-

SUBMITTER: Zhou C 

PROVIDER: S-EPMC11844280 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature