Feedback and feedforward control are differentially delayed in cerebellar ataxia.

ABSTRACT: Damage to the cerebellum can cause ataxia, a condition associated with impaired movement coordination. Typically, coordinated movement relies on a combination of anticipatory mechanisms (specifically, feedforward control) and corrective mechanisms (embodied by feedback control). Here, we show that in 3D reaching in VR, ataxia preserves the visuomotor feedforward and feedback control structure compared to the control group. However, the ataxia group exhibits a small increase in feedback delay (~ 20 ms) and a substantial increase in feedforward delay (~ 70 ms) together with a reduced feedback gain (~ 25% lower). Our results suggest that the feedforward and feedback pathways remain largely intact in ataxia, but that time delay deficits and temoral discoordination amongst these control pathway

SUBMITTER: Cao D 

PROVIDER: S-EPMC11844357 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature