Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade.

ABSTRACT: Immune checkpoint blockade can facilitate tumor clearance by T cells, resulting in long term patient survival. However, the capacity of exhausted CD8⁺ T cells (Tex), present during chronic antigen exposure, to form memory after antigen clearance remains unclear. Here, we performed longitudinal single cell RNA/T cell receptor sequencing and ATAC-sequencing on antigen-specific T cells after the clearance of chronic lymphocytic choriomeningitis virus (LCMV) infection. These data revealed the formation of a robust population of memory CD8⁺ T cells that transcriptionally, epigenetically, and functionally resemble central memory T cells (Tcm) that form after clearance of acute infection. To lineage trace the origin and memory recall response of Tex-derived memory clones, we

SUBMITTER: Raposo CJ 

PROVIDER: S-EPMC11844384 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature