Temporal dose inversion properties of adaptive biomolecular circuits.

ABSTRACT: Cells have the capacity to encode and decode information in the temporal features of molecular signals. Many pathways, for example, generate either sustained or pulsatile responses depending on the context, and such diverse temporal behaviors have a profound impact on cell fate. Here we focus on how molecular pathways can convert the temporal features of dynamic signals, in particular how they can convert transient signals into persistent downstream events and vice versa. We describe this type of behavior as temporal dose inversion, and we demonstrate that it can be achieved through adaptive molecular circuits. We consider motifs known as incoherent feedforward loop (IFFL) and negative feedback loop (NFL), and identify parametric conditions that enable temporal dose inversion. We next cons

SUBMITTER: Nakamura E 

PROVIDER: S-EPMC11844413 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature