Forward genetic screen in zebrafish identifies new fungal regulators that limit host-protective <i>Candida</i>-innate immune interaction.

ABSTRACT: Candida is one of the most frequent causes of bloodstream infections, and our first line of defense against these invasive infections is the innate immune system. The early immune response is critical in controlling C. albicans infection, but C. albicans has several strategies to evade host immune attack. Phagocytosis of C. albicans blocks hyphal growth, limiting host damage and virulence, but how C. albicans limits early recruitment and phagocytosis in vertebrate infection is poorly understood. To study innate immune evasion by intravital imaging, we utilized the transparent larval zebrafish infection model to screen 131 C. albicans mutants for altered virulence and phagocyte response. Infections with each of seven hypovirulent mutants led to alte

SUBMITTER: Blair BA 

PROVIDER: S-EPMC11844468 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature