Circuit-Based Understanding of Fine Spatial Scale Clustering of Orientation Tuning in Mouse Visual Cortex.

ABSTRACT: In sensory cortex of brain it is often the case that neurons are spatially organized by their functional properties. A hallmark of primary visual cortex (V1) in higher mammals is a columnar functional map, where neurons tuned to different stimuli features are regularly organized in space. However, rodent visual cortex is at odds with this rule and lacks any spatially ordered functional architecture, and rather neuron feature preference is haphazardly organized in patterns termed 'salt-and-pepper'. This sharp contrast in feature organization between the visual cortices of rodents and higher mammals has been a persistent mystery, fueled in part by abundant evidence of conserved cortical physiology between species. In this work, we applied a novel GCaMP indicator that are localized in the nuc

SUBMITTER: Yu P 

PROVIDER: S-EPMC11844487 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature