Fast-timescale hippocampal processes bridge between slowly unfurling neocortical states during memory search.

ABSTRACT: Prior behavioral work showed that event structure plays a key role in our ability to mentally search through memories of continuous naturalistic experience. We hypothesized that, neurally, this memory search process involves a division of labor between slowly unfurling neocortical states representing event knowledge and fast hippocampal-neocortical communication that supports retrieval of new information at transitions between events. To test this, we tracked slow neural state-patterns in a sample of ten patients undergoing intracranial electroencephalography as they viewed a movie and then searched their memories in a structured naturalistic interview. As patients answered questions ("after X, when does Y happen next?"), state-patterns from movie-viewing were reinstated in neocortex; duri

SUBMITTER: Michelmann S 

PROVIDER: S-EPMC11844493 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature