Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe for neurodegenerative diseases.

ABSTRACT:

Background

The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimer's disease (AD) and Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) indicating a potential for metrics from this region to serve as imaging biomarkers. Leveraging a unique post-mortem dataset of histology and magnetic resonance imaging (MRI) scans we aimed to 1) develop an anatomically valid segmentation protocol for anterior entorhinal cortex (ERC), Brodmann Area (BA) 35, and BA36 for in vivo 3 tesla (T) MRI and 2) incorporate this protocol in an automated approach.

Methods

We included 20 cases (61-97 years old, 50% females) with and without neurodegenerative diseases (11 vs. 9 cases) to ensure generalizability of the developed

SUBMITTER: Sadeghpour N 

PROVIDER: S-EPMC11844510 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature