A neuro-immune axis of transcriptomic dysregulation within the subgenual anterior cingulate cortex in schizophrenia.

ABSTRACT: Many genes are linked to psychiatric disorders, but genome-wide association studies (GWAS) and differential gene expression (DGE) analyses in post-mortem brain tissue often implicate distinct gene sets. This disconnect impedes therapeutic development, which relies on integrating genetic and genomic insights. We address this issue using a novel multivariate technique that reduces DGE bias by leveraging gene co-expression networks and controlling for confounds such as drug exposure. Deep RNA sequencing was performed in bulk post-mortem sgACC from individuals with bipolar disorder (BD; N=35), major depression (MDD; N=51), schizophrenia (SCZ; N=44), and controls (N=55). Toxicology data dimensionality was reduced using multiple correspondence analysis; case-control gene expression was then anal

SUBMITTER: Smith RL 

PROVIDER: S-EPMC11844519 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature