Dissociating the incubation of appetitive and consummatory behavior in a model of oral cocaine self-administration.

ABSTRACT: Cocaine use disorder remains a persistent public health dilemma that currently lacks effective treatment strategies. One key impediment to successful treatment outcomes is increased drug craving that occurs over the course of abstinence and subsequent relapse to drug use. This phenomenon, known as the incubation of drug craving, has been modeled extensively in rodent models of intravenous drug self-administration. As commonly implemented, the design of intravenous self-administration preclinical studies precludes disentangling appetitive and consummatory behaviors as drug seeking (appetitive) and taking (consummatory) is simultaneous. Here, we employed a model of oral cocaine self-administration to interrogate the incubation of drug vs nondrug craving, where the route of administration is

SUBMITTER: Namba MD 

PROVIDER: S-EPMC11844540 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature